Mechanizm kinetyczny reakcji w stanie stacjonarnym katalizowanej przez dehydrogenazę oktopinową [N2-(1-karboksyetylo)-L-arginina:NAD+ oksydoreduktaza] badano przy pH 6,9 i 9,2 w badaniach hamowania substratu, hamowania analogu i hamowania produktu . W kierunku syntezy oktopiny wzory inhibicji w obecności deltaguanidowalerianu i propionianu pokazują, że NADH wiąże się najpierw z enzymem, a następnie z L-argininą i pirogronianem, które wiążą się losowo.
W kierunku utleniania oktopiny wzorce substratów pokazują, że NAD wiąże się z enzymem przed oktopiną w szybki sposób w stanie równowagi, a wzorce inhibicji produktu pokazują, że produkty L-arginina i pirogronian są uwalniane w sposób losowy. Wykazano, że podwójne, synergistyczne hamowanie substratu przez L-argininę i pirogronian jest spowodowane wiązaniem (hipotetycznie iminy) z wolnym enzymem i kompleksem enzym-NAD. Ponadto wykazano alternatywny szlak o mniejszym znaczeniu, który obejmuje kompleks enzym-NADH-oktopina i kompleks enzym-oktopina
Dehydrogenaza oktopinowa (OcDH) z mięśnia przywodziciela przegrzebka olbrzymiego, Pecten maximus, katalizuje zależną od NADH, redukcyjną kondensację L-argininy i pirogronianu do oktopiny, NAD(+) i wody podczas pływania ucieczkowego i/lub późniejszej regeneracji.
- Niedawno rozwiązano strukturę OcDH i zaproponowano mechanizm reakcji, który implikował uporządkowane wiązanie NADH, L-argininy i wreszcie pirogronianu. W tym przypadku kolejność wiązania substratu, a także leżące u podstaw zmiany konformacyjne zostały zbadane za pomocą NMR, potwierdzając model wyprowadzony ze struktur krystalicznych. Ponadto określono strukturę krystaliczną kompleksu OcDH/NADH/agmatyna, co sugeruje kluczową rolę łańcucha bocznego L-argininy w katalizie białek.
- W ten sposób można teraz szczegółowo opisać kolejność wiązania substratu z OcDH, a także sygnały molekularne zaangażowane w tworzenie oktopiny.
- Dehydrogenaza oktopinowa [N(2)-(D-1-karboksyetylo)-L-arginina:NAD(+) oksydoreduktaza] (OcDH) z mięśnia przywodziciela przegrzebka wielkiego Pecten maximus katalizuje redukcyjną kondensację l-argininy i pirogronianu do oktopina podczas pływania ucieczkowego.
- Enzym ten, będący prototypem dehydrogenaz opinowych (OpDH), utlenia NADH pochodzący z glikolizy do NAD(+), podtrzymując w ten sposób beztlenowe dostarczanie ATP podczas krótkich okresów wzmożonej aktywności mięśni. W przeciwieństwie do niektórych innych OpDH, OcDH wykorzystuje tylko l-argininę jako substrat aminokwasowy.
- W tym miejscu opisujemy struktury krystaliczne OcDH w kompleksie z NADH i kompleksami binarnymi NADH/l-arginina i NADH/pirogronian, dostarczając szczegółowych informacji na temat zasad rozpoznawania substratu, wiązania ligandów i mechanizmu reakcji.
- OcDH wiąże swoje substraty poprzez połączenie sił elektrostatycznych i doboru wielkości, co gwarantuje, że kataliza OcDH przebiega z selektywnością substratową i stereoselektywnością, dając początek drugiemu centrum chiralnemu i wykorzystując mechanizm „linii molekularnej”.
cDNA dla dehydrogenazy oktopinowej (ODH) z mięśnia przywodziciela przegrzebka olbrzymiego, Pecten maximus, sklonowano przy użyciu 5′- i 3′-RACE. cDNA zawiera ORF o długości 1197 nukleotydów, a wydedukowana sekwencja aminokwasowa koduje białko o długości 399 aminokwasów.
ODH ulegał heterologicznej ekspresji w Escherichia coli z C-końcowym penta-tagiem His. ODH-5His oczyszczono do jednorodności stosując chromatografię powinowactwa z chelatem metalu i filtrację żelową Sephadex G-100. Rekombinowany ODH miał właściwości kinetyczne podobne do ODH typu dzikiego wyizolowanego z mięśnia przywodziciela przegrzebka. Do wyjaśnienia udziału kilku reszt aminokwasowych w reakcji katalizowanej przez ODH zastosowano ukierunkowaną mutagenezę. Cys148, która jest konserwowana we wszystkich znanych do tej pory dehydrogenazach opinowych, została przekształcona w serynę lub alaninę, co pokazuje, że ta pozostałość nie jest z natury istotna dla katalizy.
His212, Arg324 i Asp329, które są również konserwowane we wszystkich znanych sekwencjach dehydrogenazy opinowej, poddano ukierunkowanej mutagenezie. Modyfikacja tych reszt ujawniła ich znaczenie dla aktywności katalitycznej enzymu. Konwersja każdej z tych reszt do alaniny spowodowała silny wzrost wartości K(m) i spadek wartości k(cat) dla pirogronianu i L-argininy, ale miała niewielki wpływ na wartości K(m) i k(cat) dla NADH .
Zakładając podobną strukturę ODH w porównaniu z jedyną dostępną strukturą bakteryjnej dehydrogenazy opinowej, te trzy aminokwasy mogą funkcjonować jako triada katalityczna w ODH, podobna do tej występującej w dehydrogenazie mleczanowej lub dehydrogenazie jabłczanowej. Grupa karboksylowa pirogronianu jest następnie stabilizowana przez Arg324. Oprócz orientowania substratu, His212 będzie działał jako katalizator kwasowo-zasadowy, oddając proton grupie karbonylowej pirogronianu. Kwasowość tej histydyny dodatkowo zwiększa bliskość Asp32.
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Recombinant Pecten maximus Octopine dehydrogenase (odh1) |
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Recombinant Pecten maximus Octopine dehydrogenase (odh1) |
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Recombinant Pecten maximus Octopine dehydrogenase (odh1) |
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Recombinant Pecten maximus Octopine dehydrogenase (odh1) |
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| MBS1369696-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | 1270 EUR |
Recombinant Pecten maximus Octopine dehydrogenase (odh1) |
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| MBS1369696-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 945 EUR |
Recombinant Pecten maximus Octopine dehydrogenase (odh1) |
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| MBS1369696-002mgYeast | MyBiosource | 0.02mg(Yeast) | 1065 EUR |
Recombinant Pecten maximus Octopine dehydrogenase (odh1) |
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Recombinant Pecten maximus Octopine dehydrogenase (odh1) |
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Recombinant Pecten maximus Cytochrome c oxidase subunit 1 (COI), partial |
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Recombinant Pecten maximus NADH-ubiquinone oxidoreductase chain 1 (ND1), partial |
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Recombinant Mizuhopecten yessoensis Octopine dehydrogenase (odh) |
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| MBS1350530-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | 1270 EUR |
Recombinant Mizuhopecten yessoensis Octopine dehydrogenase (odh) |
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| MBS1350530-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 945 EUR |
Recombinant Mizuhopecten yessoensis Octopine dehydrogenase (odh) |
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| MBS1350530-002mgYeast | MyBiosource | 0.02mg(Yeast) | 1065 EUR |
Recombinant Mizuhopecten yessoensis Octopine dehydrogenase (odh) |
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| MBS1350530-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 1135 EUR |
Recombinant Mizuhopecten yessoensis Octopine dehydrogenase (odh) |
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D-(+)-Octopine |
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D-(+)-Octopine |
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D-(+)-Octopine |
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Recombinant Rhizobium meliloti Octopine-binding periplasmic protein (occT) |
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Recombinant Rhizobium meliloti Octopine-binding periplasmic protein (occT) |
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| MBS1101624-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 790 EUR |
Recombinant Rhizobium meliloti Octopine-binding periplasmic protein (occT) |
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Recombinant Rhizobium meliloti Octopine-binding periplasmic protein (occT) |
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Recombinant Rhizobium meliloti Octopine-binding periplasmic protein (occT) |
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Recombinant Rhizobium radiobacter Octopine-binding periplasmic protein (occT) |
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Recombinant Rhizobium radiobacter Octopine-binding periplasmic protein (occT) |
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Recombinant Rhizobium radiobacter Octopine-binding periplasmic protein (occT) |
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Recombinant Rhizobium radiobacter Octopine-binding periplasmic protein (occT) |
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Recombinant Rhizobium radiobacter Octopine-binding periplasmic protein (occT) |
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Recombinant Agrobacterium tumefaciens Octopine-binding periplasmic protein (occT) |
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Recombinant Agrobacterium tumefaciens Octopine-binding periplasmic protein (occT) |
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| MBS1205951-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 770 EUR |
Recombinant Agrobacterium tumefaciens Octopine-binding periplasmic protein (occT) |
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| MBS1205951-002mgYeast | MyBiosource | 0.02mg(Yeast) | 925 EUR |
Recombinant Agrobacterium tumefaciens Octopine-binding periplasmic protein (occT) |
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| MBS1205951-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 925 EUR |
Recombinant Agrobacterium tumefaciens Octopine-binding periplasmic protein (occT) |
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Recombinant Rhizobium meliloti Octopine permease ATP-binding protein P (occP) |
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Recombinant Rhizobium meliloti Octopine permease ATP-binding protein P (occP) |
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| MBS1261986-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 775 EUR |
Recombinant Rhizobium meliloti Octopine permease ATP-binding protein P (occP) |
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Recombinant Rhizobium meliloti Octopine permease ATP-binding protein P (occP) |
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Recombinant Rhizobium meliloti Octopine permease ATP-binding protein P (occP) |
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Recombinant Rhizobium radiobacter Octopine permease ATP-binding protein P (occP) |
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Recombinant Rhizobium radiobacter Octopine permease ATP-binding protein P (occP) |
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| MBS1172909-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 775 EUR |
Recombinant Rhizobium radiobacter Octopine permease ATP-binding protein P (occP) |
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Recombinant Rhizobium radiobacter Octopine permease ATP-binding protein P (occP) |
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Recombinant Rhizobium radiobacter Octopine permease ATP-binding protein P (occP) |
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Recombinant Rhizobium meliloti Octopine transport system permease protein occM (occM) |
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Recombinant Rhizobium meliloti Octopine transport system permease protein occM (occM) |
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Recombinant Rhizobium meliloti Octopine transport system permease protein occM (occM) |
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Recombinant Rhizobium meliloti Octopine transport system permease protein occQ (occQ) |
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Recombinant Rhizobium meliloti Octopine transport system permease protein occQ (occQ) |
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Recombinant Rhizobium meliloti Octopine transport system permease protein occQ (occQ) |
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Recombinant Agrobacterium tumefaciens Octopine permease ATP-binding protein P (occP) |
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Recombinant Agrobacterium tumefaciens Octopine permease ATP-binding protein P (occP) |
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Recombinant Agrobacterium tumefaciens Octopine permease ATP-binding protein P (occP) |
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| MBS1092743-002mgYeast | MyBiosource | 0.02mg(Yeast) | 930 EUR |
Recombinant Agrobacterium tumefaciens Octopine permease ATP-binding protein P (occP) |
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Recombinant Agrobacterium tumefaciens Octopine permease ATP-binding protein P (occP) |
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Recombinant Rhizobium radiobacter Octopine transport system permease protein occM (occM) |
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| MBS7024321-002mg | MyBiosource | 0.02mg | 1540 EUR |
Recombinant Rhizobium radiobacter Octopine transport system permease protein occM (occM) |
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Recombinant Rhizobium radiobacter Octopine transport system permease protein occM (occM) |
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Recombinant Rhizobium radiobacter Octopine transport system permease protein occQ (occQ) |
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Recombinant Rhizobium radiobacter Octopine transport system permease protein occQ (occQ) |
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| MBS7024324-01mg | MyBiosource | 0.1mg | 2490 EUR |
Recombinant Rhizobium radiobacter Octopine transport system permease protein occQ (occQ) |
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Recombinant Agrobacterium tumefaciens Octopine transport system permease protein occQ (occQ) |
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Recombinant Agrobacterium tumefaciens Octopine transport system permease protein occQ (occQ) |
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| MBS7024322-002mg | MyBiosource | 0.02mg | 1530 EUR |
Recombinant Agrobacterium tumefaciens Octopine transport system permease protein occQ (occQ) |
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| MBS7024322-01mg | MyBiosource | 0.1mg | 2490 EUR |
Recombinant Agrobacterium tumefaciens Octopine transport system permease protein occQ (occQ) |
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| MBS7024322-5x01mg | MyBiosource | 5x0.1mg | 11170 EUR |
Recombinant Rhizobium meliloti Octopine transport system permease protein occM (occM), partial |
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Recombinant Rhizobium meliloti Octopine transport system permease protein occQ (occQ), partial |
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Recombinant Rhizobium meliloti Octopine catabolism/uptake operon regulatory protein occR (occR) |
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| MBS1215906-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | 1175 EUR |
Recombinant Rhizobium meliloti Octopine catabolism/uptake operon regulatory protein occR (occR) |
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| MBS1215906-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 820 EUR |
Recombinant Rhizobium meliloti Octopine catabolism/uptake operon regulatory protein occR (occR) |
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| MBS1215906-002mgYeast | MyBiosource | 0.02mg(Yeast) | 965 EUR |
Recombinant Rhizobium meliloti Octopine catabolism/uptake operon regulatory protein occR (occR) |
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| MBS1215906-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 985 EUR |
Recombinant Rhizobium meliloti Octopine catabolism/uptake operon regulatory protein occR (occR) |
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Recombinant Rhizobium radiobacter Octopine transport system permease protein occM (occM), partial |
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Recombinant Rhizobium radiobacter Octopine transport system permease protein occQ (occQ), partial |
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Recombinant Rhizobium radiobacter Octopine catabolism/uptake operon regulatory protein occR (occR) |
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| MBS1069031-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | 1180 EUR |
Recombinant Rhizobium radiobacter Octopine catabolism/uptake operon regulatory protein occR (occR) |
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| MBS1069031-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 820 EUR |
Recombinant Rhizobium radiobacter Octopine catabolism/uptake operon regulatory protein occR (occR) |
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| MBS1069031-002mgYeast | MyBiosource | 0.02mg(Yeast) | 965 EUR |
Recombinant Rhizobium radiobacter Octopine catabolism/uptake operon regulatory protein occR (occR) |
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| MBS1069031-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 985 EUR |
Recombinant Rhizobium radiobacter Octopine catabolism/uptake operon regulatory protein occR (occR) |
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| MBS1069031-01mgYeast | MyBiosource | 0.1mg(Yeast) | 1130 EUR |
Recombinant Agrobacterium tumefaciens Octopine transport system permease protein occQ (occQ), partial |
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| MBS7062317-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Agrobacterium tumefaciens Octopine catabolism/uptake operon regulatory protein occR (occR) |
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| MBS1125384-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | 1180 EUR |
Recombinant Agrobacterium tumefaciens Octopine catabolism/uptake operon regulatory protein occR (occR) |
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| MBS1125384-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 820 EUR |
Recombinant Agrobacterium tumefaciens Octopine catabolism/uptake operon regulatory protein occR (occR) |
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| MBS1125384-002mgYeast | MyBiosource | 0.02mg(Yeast) | 965 EUR |
Recombinant Agrobacterium tumefaciens Octopine catabolism/uptake operon regulatory protein occR (occR) |
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| MBS1125384-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 985 EUR |
Recombinant Agrobacterium tumefaciens Octopine catabolism/uptake operon regulatory protein occR (occR) |
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| MBS1125384-01mgYeast | MyBiosource | 0.1mg(Yeast) | 1130 EUR |
Recombinant Elephas maximus Insulin (INS) |
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Recombinant Elephas maximus Insulin (INS) |
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Recombinant Elephas maximus Insulin (INS) |
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| MBS1029081-005mgYeast | MyBiosource | 0.05mg(Yeast) | 710 EUR |
Recombinant Elephas maximus Insulin (INS) |
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| MBS1029081-02mgEColi | MyBiosource | 0.2mg(E-Coli) | 670 EUR |
Recombinant Elephas maximus Insulin (INS) |
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Recombinant Elephas maximus Myoglobin (MB) |
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| MBS1129514-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | 1075 EUR |
Recombinant Elephas maximus Myoglobin (MB) |
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| MBS1129514-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 665 EUR |
Recombinant Elephas maximus Myoglobin (MB) |
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Recombinant Elephas maximus Myoglobin (MB) |
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Recombinant Elephas maximus Myoglobin (MB) |
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| MBS1129514-01mgYeast | MyBiosource | 0.1mg(Yeast) | 970 EUR |
Recombinant Lagostomus maximus Myoglobin (MB) |
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Recombinant Lagostomus maximus Myoglobin (MB) |
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| MBS1051099-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 665 EUR |
Recombinant Lagostomus maximus Myoglobin (MB) |
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| MBS1051099-002mgYeast | MyBiosource | 0.02mg(Yeast) | 830 EUR |
Recombinant Lagostomus maximus Myoglobin (MB) |
|||
| MBS1051099-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 770 EUR |
Recombinant Lagostomus maximus Myoglobin (MB) |
|||
| MBS1051099-01mgYeast | MyBiosource | 0.1mg(Yeast) | 970 EUR |
Recombinant Elephas maximus Aquaporin-2 (AQP2) |
|||
| MBS1163623-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Elephas maximus Aquaporin-2 (AQP2) |
|||
| MBS7007866-002mg | MyBiosource | 0.02mg | 1375 EUR |
Recombinant Elephas maximus Aquaporin-2 (AQP2) |
|||
| MBS7007866-01mg | MyBiosource | 0.1mg | 2340 EUR |
Recombinant Elephas maximus Aquaporin-2 (AQP2) |
|||
| MBS7007866-5x01mg | MyBiosource | 5x0.1mg | 10485 EUR |
Recombinant Elephas maximus Fibrinogen beta chain (FGB) |
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| MBS1000951-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | 880 EUR |
Recombinant Elephas maximus Fibrinogen beta chain (FGB) |
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| MBS1000951-005mgEColi | MyBiosource | 0.05mg(E-Coli) | 500 EUR |
Recombinant Elephas maximus Fibrinogen beta chain (FGB) |
|||
| MBS1000951-005mgYeast | MyBiosource | 0.05mg(Yeast) | 700 EUR |
Recombinant Elephas maximus Fibrinogen beta chain (FGB) |
|||
| MBS1000951-02mgEColi | MyBiosource | 0.2mg(E-Coli) | 655 EUR |
Recombinant Elephas maximus Fibrinogen beta chain (FGB) |
|||
| MBS1000951-05mgEColi | MyBiosource | 0.5mg(E-Coli) | 695 EUR |
Recombinant Elephas maximus Aquaporin-2 (AQP2), partial |
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| MBS7053713-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Elephas maximus Hemoglobin subunit beta (HBB) |
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| MBS1006616-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | 1070 EUR |
Recombinant Elephas maximus Hemoglobin subunit beta (HBB) |
|||
| MBS1006616-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 655 EUR |
Recombinant Elephas maximus Hemoglobin subunit beta (HBB) |
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| MBS1006616-002mgYeast | MyBiosource | 0.02mg(Yeast) | 820 EUR |
Recombinant Elephas maximus Hemoglobin subunit beta (HBB) |
|||
| MBS1006616-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 760 EUR |
Recombinant Elephas maximus Hemoglobin subunit beta (HBB) |
|||
| MBS1006616-01mgYeast | MyBiosource | 0.1mg(Yeast) | 960 EUR |
Recombinant Elephas maximus Hemoglobin subunit delta (HBD) |
|||
| MBS1339775-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | 1070 EUR |
Recombinant Elephas maximus Hemoglobin subunit delta (HBD) |
|||
| MBS1339775-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 655 EUR |
Recombinant Elephas maximus Hemoglobin subunit delta (HBD) |
|||
| MBS1339775-002mgYeast | MyBiosource | 0.02mg(Yeast) | 820 EUR |
Recombinant Elephas maximus Hemoglobin subunit delta (HBD) |
|||
| MBS1339775-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 760 EUR |
Recombinant Elephas maximus Hemoglobin subunit delta (HBD) |
|||
| MBS1339775-01mgYeast | MyBiosource | 0.1mg(Yeast) | 960 EUR |
Recombinant Elephas maximus Hemoglobin subunit alpha (HBA) |
|||
| MBS1086614-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | 1065 EUR |
Recombinant Elephas maximus Hemoglobin subunit alpha (HBA) |
|||
| MBS1086614-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 650 EUR |
Recombinant Elephas maximus Hemoglobin subunit alpha (HBA) |
|||
| MBS1086614-002mgYeast | MyBiosource | 0.02mg(Yeast) | 815 EUR |
Recombinant Elephas maximus Hemoglobin subunit alpha (HBA) |
|||
| MBS1086614-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 750 EUR |
Recombinant Elephas maximus Hemoglobin subunit alpha (HBA) |
|||
| MBS1086614-01mgYeast | MyBiosource | 0.1mg(Yeast) | 955 EUR |
Recombinant Elephas maximus Hemoglobin subunit gamma (HBG) |
|||
| MBS1474908-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | 1070 EUR |
Recombinant Elephas maximus Hemoglobin subunit gamma (HBG) |
|||
| MBS1474908-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 655 EUR |
Recombinant Elephas maximus Hemoglobin subunit gamma (HBG) |
|||
| MBS1474908-002mgYeast | MyBiosource | 0.02mg(Yeast) | 820 EUR |
Recombinant Elephas maximus Hemoglobin subunit gamma (HBG) |
|||
| MBS1474908-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 760 EUR |
Recombinant Elephas maximus Hemoglobin subunit gamma (HBG) |
|||
| MBS1474908-01mgYeast | MyBiosource | 0.1mg(Yeast) | 960 EUR |
Recombinant Elephas maximus Cytochrome b (MT-CYB), partial |
|||
| MBS1156768-1mgEColi | MyBiosource | 1mg(E-Coli) | 2025 EUR |
Recombinant Elephas maximus Cytochrome b (MT-CYB), partial |
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| MBS1156768-1mgYeast | MyBiosource | 1mg(Yeast) | 2470 EUR |
Recombinant Elephas maximus ATP synthase subunit a (MT-ATP6) |
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| MBS7021411-002mg | MyBiosource | 0.02mg | 1515 EUR |
Recombinant Elephas maximus ATP synthase subunit a (MT-ATP6) |
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| MBS7021411-01mg | MyBiosource | 0.1mg | 2475 EUR |
Recombinant Elephas maximus ATP synthase subunit a (MT-ATP6) |
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| MBS7021411-5x01mg | MyBiosource | 5x0.1mg | 11090 EUR |
Recombinant Elephas maximus Alpha-2B adrenergic receptor (ADRA2B) |
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| MBS1206227-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Elephas maximus Alpha-2B adrenergic receptor (ADRA2B) |
|||
| MBS7007308-002mg | MyBiosource | 0.02mg | 1705 EUR |
Recombinant Elephas maximus Alpha-2B adrenergic receptor (ADRA2B) |
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| MBS7007308-01mg | MyBiosource | 0.1mg | 2665 EUR |
Recombinant Elephas maximus Alpha-2B adrenergic receptor (ADRA2B) |
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| MBS7007308-5x01mg | MyBiosource | 5x0.1mg | 11945 EUR |
Recombinant Dipetalogaster maximus Serine protease inhibitor dipetalogastin |
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| MBS1131148-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | 1140 EUR |
Recombinant Dipetalogaster maximus Serine protease inhibitor dipetalogastin |
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| MBS1131148-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 725 EUR |
Recombinant Dipetalogaster maximus Serine protease inhibitor dipetalogastin |
|||
| MBS1131148-002mgYeast | MyBiosource | 0.02mg(Yeast) | 890 EUR |
Recombinant Dipetalogaster maximus Serine protease inhibitor dipetalogastin |
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| MBS1131148-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 870 EUR |
Recombinant Dipetalogaster maximus Serine protease inhibitor dipetalogastin |
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| MBS1131148-01mgYeast | MyBiosource | 0.1mg(Yeast) | 1045 EUR |
Recombinant Elephas maximus ATP synthase protein 8 (MT-ATP8), partial |
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| MBS1427213-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | 925 EUR |
Recombinant Elephas maximus ATP synthase protein 8 (MT-ATP8), partial |
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| MBS1427213-005mgMammalianCell | MyBiosource | 0.05mg(Mammalian-Cell) | 1150 EUR |
Recombinant Elephas maximus ATP synthase protein 8 (MT-ATP8), partial |
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| MBS1427213-05mgEColi | MyBiosource | 0.5mg(E-Coli) | 925 EUR |
Recombinant Elephas maximus ATP synthase protein 8 (MT-ATP8), partial |
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| MBS1427213-05mgYeast | MyBiosource | 0.5mg(Yeast) | 1150 EUR |
Recombinant Elephas maximus ATP synthase protein 8 (MT-ATP8), partial |
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| MBS1427213-1mgEColi | MyBiosource | 1mg(E-Coli) | 1255 EUR |
Recombinant Elephas maximus Cytochrome c oxidase subunit 2 (MT-CO2) |
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| MBS7021548-002mg | MyBiosource | 0.02mg | 1520 EUR |
Recombinant Elephas maximus Cytochrome c oxidase subunit 2 (MT-CO2) |
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| MBS7021548-01mg | MyBiosource | 0.1mg | 2480 EUR |
Recombinant Elephas maximus Cytochrome c oxidase subunit 2 (MT-CO2) |
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| MBS7021548-5x01mg | MyBiosource | 5x0.1mg | 11115 EUR |
Recombinant Elephas maximus Cytochrome c oxidase subunit 3 (MT-CO3) |
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| MBS7021700-002mg | MyBiosource | 0.02mg | 1560 EUR |
Recombinant Elephas maximus Cytochrome c oxidase subunit 3 (MT-CO3) |
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| MBS7021700-01mg | MyBiosource | 0.1mg | 2520 EUR |
Recombinant Elephas maximus Cytochrome c oxidase subunit 3 (MT-CO3) |
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| MBS7021700-5x01mg | MyBiosource | 5x0.1mg | 11295 EUR |
Recombinant Elephas maximus ATP synthase subunit a (MT-ATP6), partial |
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| MBS7076700-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Elephas maximus Alpha-2B adrenergic receptor (ADRA2B), partial |
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| MBS7053638-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Elephas maximus NADH-ubiquinone oxidoreductase chain 3 (MT-ND3) |
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| MBS7022026-002mg | MyBiosource | 0.02mg | 1385 EUR |
Recombinant Elephas maximus NADH-ubiquinone oxidoreductase chain 3 (MT-ND3) |
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| MBS7022026-01mg | MyBiosource | 0.1mg | 2350 EUR |
Recombinant Elephas maximus NADH-ubiquinone oxidoreductase chain 3 (MT-ND3) |
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| MBS7022026-5x01mg | MyBiosource | 5x0.1mg | 10520 EUR |
Recombinant Elephas maximus NADH-ubiquinone oxidoreductase chain 6 (MT-ND6) |
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| MBS7022427-002mg | MyBiosource | 0.02mg | 1455 EUR |
Recombinant Elephas maximus NADH-ubiquinone oxidoreductase chain 6 (MT-ND6) |
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| MBS7022427-01mg | MyBiosource | 0.1mg | 2420 EUR |
Recombinant Elephas maximus NADH-ubiquinone oxidoreductase chain 6 (MT-ND6) |
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| MBS7022427-5x01mg | MyBiosource | 5x0.1mg | 10835 EUR |
Recombinant Elephas maximus Cytochrome c oxidase subunit 3 (MT-CO3), partial |
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| MBS7075967-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Elephas maximus Cytochrome c oxidase subunit 1 (MT-CO1), partial |
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| MBS7076485-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Elephas maximus Cytochrome c oxidase subunit 2 (MT-CO2), partial |
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| MBS7076591-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Elephas maximus NADH-ubiquinone oxidoreductase chain 4L (MT-ND4L) |
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| MBS7022196-002mg | MyBiosource | 0.02mg | 1360 EUR |
Recombinant Elephas maximus NADH-ubiquinone oxidoreductase chain 4L (MT-ND4L) |
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| MBS7022196-01mg | MyBiosource | 0.1mg | 2325 EUR |
Recombinant Elephas maximus NADH-ubiquinone oxidoreductase chain 4L (MT-ND4L) |
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| MBS7022196-5x01mg | MyBiosource | 5x0.1mg | 10425 EUR |
Recombinant Elephas maximus NADH-ubiquinone oxidoreductase chain 3 (MT-ND3), partial |
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| MBS7076060-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Elephas maximus NADH-ubiquinone oxidoreductase chain 4 (MT-ND4), partial |
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| MBS7076170-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Elephas maximus NADH-ubiquinone oxidoreductase chain 1 (MT-ND1), partial |
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| MBS7076171-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Elephas maximus NADH-ubiquinone oxidoreductase chain 6 (MT-ND6), partial |
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| MBS7076383-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Elephas maximus NADH-ubiquinone oxidoreductase chain 2 (MT-ND2), partial |
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| MBS7076384-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Elephas maximus NADH-ubiquinone oxidoreductase chain 4L (MT-ND4L), partial |
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| MBS7076484-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Elephas maximus NADH-ubiquinone oxidoreductase chain 5 (MT-ND5), partial |
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| MBS7076590-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Priodontes maximus NADH-ubiquinone oxidoreductase chain 1 (MT-ND1), partial |
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| MBS7088739-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Octopus vulgaris Octopressin receptor (OPR) |
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| MBS7024619-002mg | MyBiosource | 0.02mg | 1750 EUR |
Recombinant Octopus vulgaris Octopressin receptor (OPR) |
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| MBS7024619-01mg | MyBiosource | 0.1mg | 2705 EUR |
Recombinant Octopus vulgaris Octopressin receptor (OPR) |
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| MBS7024619-5x01mg | MyBiosource | 5x0.1mg | 12130 EUR |
Recombinant Octopus vulgaris Octopressin receptor (OPR), partial |
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| MBS7083973-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Bombyx mori Octopamine receptor |
|||
| MBS7036759-002mg | MyBiosource | 0.02mg | 1825 EUR |
Recombinant Bombyx mori Octopamine receptor |
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| MBS7036759-01mg | MyBiosource | 0.1mg | 2755 EUR |
Recombinant Bombyx mori Octopamine receptor |
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| MBS7036759-5x01mg | MyBiosource | 5x0.1mg | 12365 EUR |
Recombinant Octopus vulgaris Cephalotocin |
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| MBS1241542-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | 870 EUR |
Recombinant Octopus vulgaris Cephalotocin |
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| MBS1241542-005mgEColi | MyBiosource | 0.05mg(E-Coli) | 485 EUR |
Recombinant Octopus vulgaris Cephalotocin |
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| MBS1241542-005mgYeast | MyBiosource | 0.05mg(Yeast) | 705 EUR |
Recombinant Octopus vulgaris Cephalotocin |
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| MBS1241542-02mgEColi | MyBiosource | 0.2mg(E-Coli) | 635 EUR |
Recombinant Octopus vulgaris Cephalotocin |
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| MBS1241542-05mgEColi | MyBiosource | 0.5mg(E-Coli) | 695 EUR |
Recombinant Octopus vulgaris Tachykinin-1 |
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| MBS7092685-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | 875 EUR |
Recombinant Octopus vulgaris Tachykinin-1 |
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| MBS7092685-005mgEColi | MyBiosource | 0.05mg(E-Coli) | 490 EUR |
Recombinant Octopus vulgaris Tachykinin-1 |
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| MBS7092685-005mgYeast | MyBiosource | 0.05mg(Yeast) | 695 EUR |
Recombinant Octopus vulgaris Tachykinin-1 |
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| MBS7092685-02mgEColi | MyBiosource | 0.2mg(E-Coli) | 640 EUR |
Recombinant Octopus vulgaris Tachykinin-1 |
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| MBS7092685-05mgEColi | MyBiosource | 0.5mg(E-Coli) | 695 EUR |
Recombinant Octopus vulgaris Tachykinin-2 |
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| MBS7093717-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | 875 EUR |
Recombinant Octopus vulgaris Tachykinin-2 |
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| MBS7093717-005mgEColi | MyBiosource | 0.05mg(E-Coli) | 490 EUR |
Recombinant Octopus vulgaris Tachykinin-2 |
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| MBS7093717-005mgYeast | MyBiosource | 0.05mg(Yeast) | 695 EUR |
Recombinant Octopus vulgaris Tachykinin-2 |
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| MBS7093717-02mgEColi | MyBiosource | 0.2mg(E-Coli) | 640 EUR |
Recombinant Octopus vulgaris Tachykinin-2 |
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| MBS7093717-05mgEColi | MyBiosource | 0.5mg(E-Coli) | 695 EUR |
Recombinant Octopus vulgaris Sperm protamine P3 |
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| MBS1143278-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | 885 EUR |
Recombinant Octopus vulgaris Sperm protamine P3 |
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| MBS1143278-005mgEColi | MyBiosource | 0.05mg(E-Coli) | 505 EUR |
Recombinant Octopus vulgaris Sperm protamine P3 |
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| MBS1143278-005mgYeast | MyBiosource | 0.05mg(Yeast) | 705 EUR |
Recombinant Octopus vulgaris Sperm protamine P3 |
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| MBS1143278-02mgEColi | MyBiosource | 0.2mg(E-Coli) | 660 EUR |
Recombinant Octopus vulgaris Sperm protamine P3 |
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| MBS1143278-05mgEColi | MyBiosource | 0.5mg(E-Coli) | 705 EUR |
Recombinant Octopus vulgaris Sperm protamine P1 |
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| MBS1167070-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | 980 EUR |
Recombinant Octopus vulgaris Sperm protamine P1 |
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| MBS1167070-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 540 EUR |
Recombinant Octopus vulgaris Sperm protamine P1 |
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| MBS1167070-002mgYeast | MyBiosource | 0.02mg(Yeast) | 735 EUR |
Recombinant Octopus vulgaris Sperm protamine P1 |
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| MBS1167070-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 645 EUR |
Recombinant Octopus vulgaris Sperm protamine P1 |
|||
| MBS1167070-01mgYeast | MyBiosource | 0.1mg(Yeast) | 860 EUR |
Recombinant Octopus vulgaris Sperm protamine P5 |
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| MBS1170733-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | 890 EUR |
Recombinant Octopus vulgaris Sperm protamine P5 |
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| MBS1170733-005mgEColi | MyBiosource | 0.05mg(E-Coli) | 510 EUR |
Recombinant Octopus vulgaris Sperm protamine P5 |
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| MBS1170733-005mgYeast | MyBiosource | 0.05mg(Yeast) | 710 EUR |
Recombinant Octopus vulgaris Sperm protamine P5 |
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| MBS1170733-02mgEColi | MyBiosource | 0.2mg(E-Coli) | 670 EUR |
Recombinant Octopus vulgaris Sperm protamine P5 |
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| MBS1170733-05mgEColi | MyBiosource | 0.5mg(E-Coli) | 715 EUR |
Recombinant Octopus vulgaris Sperm protamine P4 |
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| MBS1063646-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | 890 EUR |
Recombinant Octopus vulgaris Sperm protamine P4 |
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| MBS1063646-005mgEColi | MyBiosource | 0.05mg(E-Coli) | 510 EUR |
Recombinant Octopus vulgaris Sperm protamine P4 |
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| MBS1063646-005mgYeast | MyBiosource | 0.05mg(Yeast) | 705 EUR |
Recombinant Octopus vulgaris Sperm protamine P4 |
|||
| MBS1063646-02mgEColi | MyBiosource | 0.2mg(E-Coli) | 670 EUR |
Recombinant Octopus vulgaris Sperm protamine P4 |
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| MBS1063646-05mgEColi | MyBiosource | 0.5mg(E-Coli) | 710 EUR |
Recombinant Octopus vulgaris Tubulin alpha chain |
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| MBS1117659-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | 1125 EUR |
Recombinant Octopus vulgaris Tubulin alpha chain |
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| MBS1117659-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 750 EUR |
Recombinant Octopus vulgaris Tubulin alpha chain |
|||
| MBS1117659-002mgYeast | MyBiosource | 0.02mg(Yeast) | 910 EUR |
Recombinant Octopus vulgaris Tubulin alpha chain |
|||
| MBS1117659-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 900 EUR |
Recombinant Octopus vulgaris Tubulin alpha chain |
|||
| MBS1117659-01mgYeast | MyBiosource | 0.1mg(Yeast) | 1065 EUR |
Recombinant Octopus vulgaris S-crystallin 3 (OCTS3) |
|||
| MBS1472408-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | 1135 EUR |
Recombinant Octopus vulgaris S-crystallin 3 (OCTS3) |
|||
| MBS1472408-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 720 EUR |
Recombinant Octopus vulgaris S-crystallin 3 (OCTS3) |
|||
| MBS1472408-002mgYeast | MyBiosource | 0.02mg(Yeast) | 885 EUR |
Stereospecyficzność dehydrogenazy oktopinowej z guza żółciowego korony i dehydrogenazy oktopinowej z przegrzebków (maksimum Pectena) w odniesieniu do utleniania C-4 pierścienia dihydronikotynamidowego NADH badano poprzez określenie rozkładu radioaktywności po utlenieniu (4R)- i (4S)-[4-3H]NADH. Dehydrogenaza oktopinowa z guza koronowego i przegrzebków stereospecyficznie usuwa atom wodoru pro-S pierścienia dihydronikotynamidu z przeniesieniem znacznika do rozpuszczalnika i do produktu oktopiny (N-2-(1-karboksyetylo)-L-arginina). Chociaż w mniejszym stopniu, wymiana znacznika z (4S)-[4-3H]NADH z rozpuszczalnikiem wystąpiła, gdy dehydrogenaza oktopinowa z guza żółciowego korony lub z przegrzebków była inkubowana bez innych substratów. Omówiono możliwe mechanizmy wyjaśniające tę wymianę.